Decoding Living Systems One Cell at a Time - Technology Networks
WEBSep 17, 2024 · Aging is characterized by the loss of cell function over time and because it affects different organs and cell types to varying degrees, single-cell analysis can provide a detailed molecular picture of age-related changes in individual cells. In the nervous system, aging has been shown to affect the composition and function of microglia ...
Understanding Single-Cell Sequencing, How It Works and Its …
WEBJan 20, 2022 · Traditional next-generation sequencing (NGS) examines the genome of a cell population, such as a cell culture, a tissue, an organ or an entire organism.Its output is the “average genome” of the cell population. On the other hand, single-cell sequencing measures the genomes of individual cells from a cell population. 5 Nowadays, traditional methods are thus referred to as bulk sequencing to ...
Neuroimaging Techniques and What a Brain Image Can Tell Us
WEBJul 7, 2022 · Neuroimaging is a discipline that deals with the in vivo depiction of the structure, function and pharmacology of the central nervous system (CNS), particularly our brain, in a noninvasive manner. 1, 2 The past two decades have witnessed remarkable strides in the development of new anatomical and functional imaging techniques that can shed light on many critical aspects of human brain function ...
Blood Nanoparticles With Potential To Transform Cancer Diagnosis ...
WEBAug 19, 2024 · The research team named these RNA molecules "EV-UGRs" (short for Extracellular Vesicles-Associated Unannotated Genomic Regions) after discovering them in the blood and urine of prostate cancer patients. UGRs are often referred to as the “dark matter” of the human genome. They are believed to …
Largest Collection of Sarcoma Patient-Derived Organoids Pave the …
WEB1 day ago · Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have developed the largest collection of sarcoma patient-derived organoids to date that can help improve the understanding of the disease and better identify therapies that are most likely to work for each individual patient.. The approach, detailed in the journal Cell Stem Cell, uses patients’ own tumor cells that ...
Machine Learning and Genomics Reveal Secrets of Cholera Pathogen
WEB1 day ago · The innovative research combines machine learning, genomics, genome-scale metabolic modelling (GSMM), and 3D structural analysis to uncover the genetic secrets of Vibrio cholerae – the bacteria behind cholera. Cholera is a deadly diarrheal disease, that continues to threaten millions worldwide, with up to 4 million cases and as many as ...
PCR - Technology Networks
WEBAn Introduction to PCR. Polymerase chain reaction (PCR) is a technique that has revolutionized the world of molecular biology and beyond. In this article, we will discuss a brief history of PCR and its principles, highlighting the different types of PCR and the specific purposes to which they are being applied. Advertisement.
DNA Synthesis: Approaches, Advances and Applications
WEBSep 25, 2020 · The success of the chemical DNA synthesis method has been phenomenal, and advances have led to higher throughput, less reagent consumption and a reduced cost. However, DNA synthesis via phosphoramidites is inherently limited by its chemistry. Even though reactions routinely proceed with >99.2% coupling efficiency per …
One Step Closer to a System That Can Detect Any Virus
WEBDec 22, 2023 · To bridge this gap, in 2015, scientists at the Center for Infection and Immunity (CII) at Columbia University Mailman School of Public Health introduced a powerful NGS-based screening and surveillance system called VirCapSeq-VERT which can detect any virus that can potentially infect humans, known or unknown, with greater sensitivity and speed ...
Clearer Diagnostics, Improved Chances: The Big-Picture Impacts of ...
WEBFeb 14, 2024 · Explore how innovations in the cancer diagnostic space, particularly those focusing on simple but effective diagnostic methodologies, could make cancer screening and early detection more straightforward, improving access and outcomes for patients.