The EMBO Journal5d
Hair follicle stem cells and the collapse of self-tolerance in alopecia: the interplay of barrier function, the microbiome, and immunity
The hair follicle is a dynamic miniature organ. Its permanent portion opens to the skin surface, communicates with sebaceous ...
The EMBO Journal3d
The winter holidays are glorious—except when they’re not
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and ...
The EMBO Journal9d
Rett syndrome: interferon-γ to the rescue?
In conclusion, this intriguing report builds on the work of many other groups by further unraveling MECP2 function in the ...
The EMBO Journal12d
TRPC5: a new entry to the chromaffin cell’s palette of ion channels that control adrenal response to hypoglycemia
Hypoglycemia is an extremely common side effect of insulin therapy experienced mainly by patients with type 1 diabetes ...
The EMBO Journal8d
Making contact away from home: a bacterial secreted effector mediates inter-organelle communication
Inter-organelle communication via the formation of membrane contact sites (MCS) is essential for cell homeostasis. Bacterial pathogens residing in membrane bound vacuoles have exploited this ...
The EMBO Journal2d
APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia
In the early phase of Alzheimer’s disease, astrocytes are the primary source of APOE in the brain. This study examined the ...
The EMBO Journal4d
Circadian rhythms of macrophages are altered by the acidic tumor microenvironment
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Tumor-associated macrophages (TAMs) are prime ...
The EMBO Journal5d
PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Poly(ADP-ribose) polymerase 1 (PARP1) is one ...
The EMBO Journal5d
Glutamine sensing licenses cholesterol synthesis
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The mevalonate pathway produces essential ...
The EMBO Journal10d
Rab2A-mediated Golgi-lipid droplet interactions support very-low-density lipoprotein secretion in hepatocytes
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Lipid droplets (LDs) serve as crucial hubs for ...
The EMBO Journal21d
Cyclophilin D plays a critical role in the survival of senescent cells
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Senescent cells present an excessive flux of ...
The EMBO Journal17d
Deep quantification of substrate turnover defines protease subsite cooperativity
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Substrate specificity determines protease ...