eLife14h
Science Communication: Tips for promoting your research
Effectively communicating your research can help to maximise its impact in your field and communities. We share some advice on how to broaden the reach of your findings, and ensure that your message ...
eLife1d
Exercise training at different intensities induces heat stress, disrupts barrier function and alters microbiota in the gut of mice
This valuable study examines how different exercise training intensities affect intestinal barrier function and gut microbiota composition over a 6-week period in mice. The evidence supporting the ...
eLife1d
Neuronal Development: Rethinking sensorimotor circuits
New research shows that the neural circuit responsible for stabilising gaze can develop in the absence of motor neurons, contrary to a long-standing model in the field.
eLife1d
Mistargeted retinal axons form synaptically segregated subcircuits in the visual thalamus of albino mice
Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, USA ...
eLife2d
The promise and peril of comparing fluorescence lifetime in biology revealed by simulations
Fluorescence lifetime imaging microscopy (FLIM) excels over the widely used fluorescence intensity imaging by allowing the measurement of absolute signal levels, independent of sensor concentration.
eLife1d
Computational method pinpoints how cause-and-effect relationships ebb and flow over time
A new computer model can more accurately assess how causal relationships in complex real-world systems vary over time.
eLife3d
Transcriptional pattern enriched for synaptic signaling is associated with shorter survival of patients with high-grade serous ovarian cancer
Penn Ovarian Cancer Research Center and Basser Center for BRCA, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States ...
eLife3d
PointTree: Automatic and accurate reconstruction of long-range axonal projections of single-neuron
This important paper takes a novel approach to the problem of automatically reconstructing long-range axonal projections from stacks of images. The key innovation is to separate the identification of ...
eLife3d
Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in obesity
Department of Physiology, Harold Hamm Diabetes Center, The University of Oklahoma Health Science Center, Oklahoma City, United States ...
eLife2d
DendroTweaks: An interactive approach for unraveling dendritic dynamics
This manuscript introduces DendroTweaks, a useful web application and Python library that, compared to existing modeling tools, eases interactive graphical exploration, development, and validation of ...
eLife5d
Endogenous FGFs drive ERK-dependent cell fate patterning in 2D human gastruloids
This work is an important contribution to understanding the role of FGF signaling in the induction of primitive-like cells in a 2D system of human gastrulation. The authors provide compelling evidence ...
eLife7d
Adaptive Integration of Perceptual and Reward Information in an Uncertain World
Perceptual uncertainty and salience both impact decision-making, but how these factors precisely impact trial-and-error reinforcement learning is not well understood. Here, we test the hypotheses that ...