Nearly 50,000 members of the International Longshoremen’s Association (ILA) are on strike Tuesday against the nation’s East and Gulf Coast ports, according to the Associated Press, choking off the flow of many of the nation’s imports and exports in what could become America’s most disruptive work stoppage in decades.

Thousands of dockworkers at more than a dozen ports along the East Coast and Gulf Coasts are poised to walk off the job on Tuesday.

The strike would be the first along ports on the East Coast in nearly 50 years, potentially crippling several industries.