The EMBO Journal2d
APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia
In the early phase of Alzheimer’s disease, astrocytes are the primary source of APOE in the brain. This study examined the ...
The EMBO Journal3d
The winter holidays are glorious—except when they’re not
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and ...
The EMBO Journal4d
Circadian rhythms of macrophages are altered by the acidic tumor microenvironment
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Tumor-associated macrophages (TAMs) are prime ...
The EMBO Journal5d
PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Poly(ADP-ribose) polymerase 1 (PARP1) is one ...
The EMBO Journal5d
Hair follicle stem cells and the collapse of self-tolerance in alopecia: the interplay of barrier function, the microbiome, and immunity
The hair follicle is a dynamic miniature organ. Its permanent portion opens to the skin surface, communicates with sebaceous ...
The EMBO Journal5d
Glutamine sensing licenses cholesterol synthesis
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The mevalonate pathway produces essential ...
The EMBO Journal7d
PTGS is dispensable for the initiation of epigenetic silencing of an active transposon in Arabidopsis
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. PTGS facilitates but is not required for the ...
The EMBO Journal7d
In situ cell-surface conformation of the TCR-CD3 signaling complex
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The extracellular molecular organization of ...
The EMBO Journal7d
Leishmania protein KMP-11 modulates cholesterol transport and membrane fluidity to facilitate host cell invasion
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The first step of successful infection by any ...
The EMBO Journal8d
The USP12/46 deubiquitinases protect integrins from ESCRT-mediated lysosomal degradation
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The functions of integrins are tightly ...
The EMBO Journal8d
Making contact away from home: a bacterial secreted effector mediates inter-organelle communication
Inter-organelle communication via the formation of membrane contact sites (MCS) is essential for cell homeostasis. Bacterial pathogens residing in membrane bound vacuoles have exploited this ...